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May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
May-Hegglin Anomaly (MHA) is a blood disorder that causes the formation of abnormally-large platelets, which can result in symptoms such as skin lesions and lowered platelet counts. This variant of the disease, caused by a dominant mutation to the gene MYH9, has been observed in the Pug.
Clinical features
Affected dogs display thrombocytopenia (lowered blood platelet counts), but might not necessarily develop any bleeding problems. Additionally, an affected dog may develop skin lesions and white plaques in the mouth following immunosuppressive treatment.
Additional information
References
Pubmed ID: 21554370
Omia ID: 1608
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