57,48 47,50 excl. VAT


Coat colour in dogs is controlled by a wide range of different genes working together.

10 working days






Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance


Also known as

Year Published

General information

Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Harlequin, or H-locus, which corresponds to the gene PSMB7, is a particular locus that can affect the coat colour and pattern of the Great Dane. In dogs that also express Merle (M-locus mutation), the dominant mutation to the H-locus further modifies the coat colour, resulting in an unpigmented white base with irregular black spots. Harlequin cannot be expressed if the dog does not produce dark pigment (governed by the E-locus).
The Harlequin mutation is believed to be homozygous lethal, meaning that only carriers will be born.

Clinical features

Affected dogs that would otherwirse have a Merle pattern develop a Harlequin pattern instead. Harlequin dogs have a lighter, unpigmented base coat with larger black or dark spots. As the mutation is likely homozygous lethal, breeding two Harlequin carriers together may result in a smaller than usual litter size.

Additional information

Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.


Pubmed ID: 21256207

Omia ID: 1454

How does it work?

Learn more

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

Related products