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Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision.
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Specifications
| Breeds | Chinese Crested, Cardigan Welsh Corgi, Pembroke Welsh Corgi, Pomeranian |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision. This early-onset variant of the disease, known as Rod-Cone Dysplasia 3 (rcd3, or rcd3-PRA), occurs in the Corgi. It is caused by a recessive mutation to the gene PDE6A.
There is some scientific evidence that this mutation also occurs in the Pomeranian and Chinese Crested Dog.
Clinical features
The main symptom of rcd3 is a progressive loss of vision, which becomes apparent between 6 and 16 weeks of age. Affected dogs are usually blind by the age of 1 year. However, a limited amount of central vision may be retained as late as 3 or 4 years of age.
Additional information
The study identifying this mutation in the Pomeranian and Chinese Crested Dog is still a preliminary publication, and may be subject to change.
References
Pubmed ID: 10393029
Omia ID: 1314
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