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Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris.
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Specifications
| Breeds | Altai, British Longhair, Exotic Longhair, Exotic Shorthair, British Shorthair, Persian, Ragdoll, Sphynx |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris. It is often due to genetics and is commonly seen in certain breeds. One of the genes involved in this trait is the Paired Box 3 (PAX3) gene. Mutations in the gene can result in white spotting, deafness, pigmentary disturbances in one or two eyes and in some cases also embryonic or fetal lethality.
There are multiple mutations known. The variant tested here is found in British Longhair, British Shorthair, Persian, Ragdoll, Sphynx and Altai cats.
Clinical features
Cats with this mutation show one or two blue eyes or particolored eyes and minimal white spotting. This does not necessarily indicate any underlying health issues. In different feline breeding lines deafness has been identified as being associated with this trait.
Additional information
References
Pubmed ID: 38997957
Omia ID: 1688