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K385

Blood coaggulation, blood clotting, is an important process to stop the bleeding at a wound site.

10 working days

Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Year Published

General information

Blood coaggulation, blood clotting, is an important process to stop the bleeding at a wound site. This process is mediated by multiple factors contributing to the coagulation cascade. One of the factors is plasma coagulation factor XII (FXII).

This test detects a DNA variant that is associated with a decrease in FXII activity causing difficulties in blood coagulation.

Clinical features

This variant leads to FXII deficiency. Cats homozygous for this mutation have severe deficiency and cats that are heterozygous have a moderate reduction in FXII activity. The mutation is predicted to result in CRM-negative deficient plasma.

Additional information

In literature in autosomal recessive inheritance pattern is suggested, but also describes mild clinical features in cats heterozygous for this variant.

References

Pubmed ID: 24793828

Omia ID: 364

How does it work?

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1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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