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Blood coaggulation, blood clotting, is an important process to stop the bleeding at a wound site.
12 working days
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
|Mode of Inheritance|
Blood coaggulation, blood clotting, is an important process to stop the bleeding at a wound site. This process is mediated by multiple factors contributing to the coagulation cascade. One of the factors is plasma coagulation factor XII (FXII).
This test detects a DNA variant that is associated with a decrease in FXII activity causing difficulties in blood coagulation.
This variant leads to FXII deficiency. Cats homozygous for this mutation have severe deficiency and cats that are heterozygous have a moderate reduction in FXII activity. The mutation is predicted to result in CRM-negative deficient plasma.
In literature in autosomal recessive inheritance pattern is suggested, but also describes mild clinical features in cats heterozygous for this variant.
Pubmed ID: 24793828
Omia ID: 364