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Dominant White and White Spotting are controlled by the KIT-gene.
20 working days
Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
General information
Dominant White and White Spotting are controlled by the KIT-gene. Dominant white is also described as the W-locus and White Spotting as the S-locus. The KIT-gene has three variants (alleles). The DW allele is dominant over the alleles Ws and N; allele Ws is dominant over allele N.
Clinical features
The dominant allele DW results in a white coat colour. One or two copies of the DW allele will result in a white cat with varying degrees of hearing impairment. The allele Ws in white spotting and the allele N has no effect on the coat colour.
Additional information
The gene/genes controlling the pattern of White Spotting is still unknown. Additionally, not all white spots or patterns result from the KIT-gene as other genes can also have mutations that result in depigmentation phenotypes. Dominant White is distinct from albinism (C-locus) which results from a mutation in the TYR gene that has no known impact on hearing.
References
Pubmed ID: 25085922
Omia ID: 209
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