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Canine degenerative myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord.
10 working days
Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Canine degenerative myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord. Neurodegenerative diseases are characterised by progressive loss of neurons in the central nervous system (CNS) which leads to deficiencies in function. In the case of DM, the affected region is the spinal cord, which results in ataxia (a loss of coordination). DM is similar in many ways to Amyotrophic Lateral Sclerosis (ALS) in humans.
This variant of the disease occurs specifically in the Bernese Mountain Dog. It is caused by a recessive mutation to the gene SOD1.
Clinical features
Most dogs are at least 8 years of age at the onset of the first clinical signs which include hyporeflexia, spasticity and ataxia of the pelvic with progression over time to complete paralysis.
Additional information
This test is performed by an external laboratory. CombiBreed takes care of the mediation between you as a customer and the external laboratory. In this case, CombiBreed cannot be held liable for the behaviour of the client and/or contractor.
References
Pubmed ID: 21628865
Omia ID: 263
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