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The bobtail or brachyury trait is caused by an autosomal dominant mutation in the T-box transcription factor T (TBXT) gene.

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General information

The bobtail or brachyury trait is caused by an autosomal dominant mutation in the T-box transcription factor T (TBXT) gene. The TBXT or T-gene encodes transcription factors that play critical roles in embryonic development, especially the tail and spine. A single copy of the mutation (heterozygous) causes the bobtail look, but two copies (homozygous mutant) disrupt development so severely that the embryo cannot survive. This makes the mutation homozygous lethal.

The tested mutation was originally discovered in the Pembroke Welsh Corgi, but also causes distinctive short tails in multiple other breeds, mainly sheepdogs and hunting breeds.

Clinical features

Dogs with one copy of the mutation have a naturally short or missing tail. If a puppy inherits two copies (homozygous mutant), it usually dies before birth due to the complete turn-off of the gene.

Additional information

The T gene mutation is not present in all breeds of short-tailed dogs, and therefore another genetic factor is possible affecting the tail phenotype in for example Spaniels, Schnauzers and Rottweilers.

References

Pubmed ID: 11252170

Omia ID: 975

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.