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In Doberman Pinschers von Willebrand disease (vWd) type I is caused in the VWF gene.
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Specifications
Breeds | Barbet, Danish-Swedish Farmdog, Drentsche Patrijshond, German Pinscher, Grand Basset Griffon Vendéen, Havanese, Manchester Terrier (Standard), Manchester Terrier (Toy), Poodle (Standard), Cardigan Welsh Corgi, Coton de Tulear, Doberman, Dutch Shepherd, Irish Setter, Kerry Blue Terrier, Kromfohrländer, Papillon, Pembroke Welsh Corgi, West Highland White Terrier |
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Gene | |
Organ | |
specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
Mode of Inheritance | |
Chromosome | |
Year Published |
General information
In Doberman Pinschers von Willebrand disease (vWd) type I is caused in the VWF gene. The von Willebrand disease is a bleeding disorder, during the disease the “von Willebrand factor” is affected in the plasma, this factor is important for blood clotting. Therefore, the blood clotting is disturbed which leads to bleeding symptoms.
Clinical features
Bleeding symptoms, like excessive bleeding during surgeries, birth or neutering.
Additional information
Inheritance of this disease is described as autosomal recessive trait in most breeds, the Kromfohrländer breed is a special case which follows an autosomal dominant inheritance mode with incomplete penetrance.
References
Pubmed ID: 23911791, 31131110, 27525650
Omia ID: 1057