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H708

Canine Spongiform Leukoencephalomyelopathy (SLEM), also known as simply Leukodystrophy, is a severe degenerative neurological disease that causes weakness, paralysis and spastic movement.

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Specifications

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Year Published

General information

Canine Spongiform Leukoencephalomyelopathy (SLEM), also known as simply Leukodystrophy, is a severe degenerative neurological disease that causes weakness, paralysis and spastic movement. The disorder is caused by a mitochondrial mutation to the gene CYTB, and is found in the Australian Cattle Dog and the Shetland Sheepdog.

Clinical features

Affected puppies usually begin presenting with whole-body tremors at approximately 3 to 4 weeks of age. They are initially able to walk, but progressively lose coordination over several weeks of development. Other symptoms include spastic twitches of the limbs, jaw drop, difficulty swallowing, excessive salivation, failure to grow and an inability to walk. The disease is progressive, and affected dogs are typically euthanized on humane grounds.

Additional information

References

Pubmed ID: 16026996

Omia ID: 1130

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2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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