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Juvenile Brain Disease (JBD), also known as Juvenile Encephalopathy, is a severe neurological condition.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
General information
Juvenile Brain Disease (JBD), also known as Juvenile Encephalopathy, is a severe neurological condition. It causes a lack of coordination in movement, severe brain deterioration and epilepsy. The disease is caused by an autosomal recessive mutation to the pitrilysin metallopeptidase 1 (PITRM1) gene. It is observed in the Parson Russell Terrier and Jack Russel Terrier.
Clinical features
The main symptoms typically appear between 6 and 12 weeks of age. Affected puppies suffer from progressively worsening epileptic seizures, with rapid disease progression leading to permanent brain damage and ultimately death. The brain damage can cause lack of coordination (ataxia) and difficulty with movement. Some dogs also may have vision issues due to brain damage affecting visual processing. Most affected puppies do not survive beyond a few months of age due to the severity of the disease.
Additional information
References
Pubmed ID: 33835239
Omia ID: 2324