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Juvenile Addison's Disease (JADD) in dogs is a autosomal recessive autoimmune disorder that affects the adrenal glands, leading to insufficient production of essential steroid hormones.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Juvenile Addison’s Disease (JADD) in dogs is a autosomal recessive autoimmune disorder that affects the adrenal glands, leading to insufficient production of essential steroid hormones. This condition is also known as primary hypoadrenocorticism. The mutation responsible for JADD is linked to genes encoding the enzymes involved in adrenal hormone production. Particularly the enzymes necessary for cortisol and aldosterone synthesis. The mutation is observed in the Nova Scotia Duck Tolling Retriever, or Toller breed.
Clinical features
The natural steroid hormones secreted by the adrenal glands are necessary for the regulation of glucose metabolism, immune function (glucocorticoids), and sodium and potassium levels in the blood (mineralocorticoids). The clinical signs of Addison’s disease can include lethargy and weakness, lack of appetite, vomiting or diarrhea, dehydration or increased drinking and urination, hypoglycemia and shaking or tremors. In severe cases, an "Addisonian crisis" may occur, causing the dog to collapse completely and go into shock. The average age of puppies affected with JADD is 5 months, though it has been observed in animals of 2 months of age. Puppies can have other concurrent symptoms including eye problems (corneal edema, conjunctivitis, or uveitis) that may require additional treatment.
Additional information
References
Pubmed ID: Thesis University of California, Davis campus
Omia ID: