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K711

Polycystic Kidney Disease (PKD) occurs frequently in cats.

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Specifications

Breeds

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Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Polycystic Kidney Disease (PKD) occurs frequently in cats. During the life of an affected cat, cysts appear in the kidneys. These cysts put pressure on the healthy kidney tissue, which leads to a loss of function of the affected kidneys.

The disease is caused by a dominant mutation to the gene PKD1, and occurs primarily in Persian cats and Persian-related breeds, but also in breeds such as the American Shorthair, Muchkin and Scottish Fold. The mutation is likely homozygous lethal, meaning that matings between carriers can only result in either carriers (heterozygous) or unaffected cats, not fully affected (homozygous) cats.

Clinical features

Polycystic Kidney Disease causes progressive loss of kidney function. The symptoms become apparent at an adult age. Symptoms are loss of appetite, excessively drinking and urinating, vomiting, lethargy and otherwise altered behaviour.

Mating two carriers may result in a smaller litter size, as homozygous (affected) embryos spontaneously abort.

Additional information

References

Pubmed ID: 15466259

Omia ID: 807

How does it work?

1. Select your product(s)

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2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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