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Neuroaxonal Dystrophy (NAD) is a degenerative neural disease that causes nerve damage, loss of motor function and paralysis.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Neuroaxonal Dystrophy (NAD) is a degenerative neural disease that causes nerve damage, loss of motor function and paralysis. This lethal variant of the disease, known as Fetal-Onset Neuroaxonal Dystrophy (FNAD), was first observed in a Schnauzer and Beagle cross. It is caused by a recessive mutation to the gene MFN2.
Clinical features
Affected puppies are born with immobilized limb joints and with scoliosis of the spine. They are unable to breathe independently, and are either stillborn or die shortly after birth.
Additional information
References
Pubmed ID: 20653033
Omia ID: 2153
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