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Neuroaxonal Dystrophy (NAD) is a severe, degenerative neurological disease that causes a loss of muscle coordination and damages the senses.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Neuroaxonal Dystrophy (NAD) is a severe, degenerative neurological disease that causes a loss of muscle coordination and damages the senses. The disorder occurs in the Papillon, and is caused by a recessive mutation to the gene PLA2G6.
Clinical features
Neuroaxonal Dystrophy leads to an uncoordinated gait, dragging of the paws or not knowing where their limbs are relative to the ground. Other symptoms can include blindness and strabismus (wandering eye). Onset of signs is typically between 6 and 18 months of age and follows a progressive course of cognitive and motor regression and hypotonia. Due to poor quality of life, affected dogs are typically euthanized on humane grounds.
Additional information
References
Pubmed ID: 28107443
Omia ID: 2105
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