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H890

Neuroaxonal Dystrophy (NAD) is a severe, degenerative neurological disease that causes a loss of muscle coordination and damages the senses.

10 working days

Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Neuroaxonal Dystrophy (NAD) is a severe, degenerative neurological disease that causes a loss of muscle coordination and damages the senses. The disorder occurs in the Papillon, and is caused by a recessive mutation to the gene PLA2G6.

Clinical features

Neuroaxonal Dystrophy leads to an uncoordinated gait, dragging of the paws or not knowing where their limbs are relative to the ground. Other symptoms can include blindness and strabismus (wandering eye). Onset of signs is typically between 6 and 18 months of age and follows a progressive course of cognitive and motor regression and hypotonia. Due to poor quality of life, affected dogs are typically euthanized.

Additional information

References

Pubmed ID: 28107443

Omia ID: 2105

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2. Collect DNA sample

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3. Results

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