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H417

Leukoencephalomyeolopathy (LEMP) is a neurological disease that affects the central nervous system, affecting coordination and gait.

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Specifications

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Leukoencephalomyeolopathy (LEMP) is a neurological disease that affects the central nervous system, affecting coordination and gait. The variant of the disease in this test occurs in the Great Dane and Rottweiler, and is caused by a recessive mutation to the gene LEMP. Another variant has been observed in the Leonberger.

Clinical features

Onset of LEMP occurs in juvenile dogs. Symptoms include slowly worsening gait abnormalities such as paw "knuckling", dragging of the paws, and hypermetria (overstepping while walking) of the front legs. The disease progresses over a matter of months.

Additional information

References

Pubmed ID: 29643404

Omia ID: 1788

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2. Collect DNA sample

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3. Results

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