€57,48 €47,50 excl. VAT
Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination.
10 working days
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
|Mode of Inheritance|
|Also known as|
Leukoencephalomyelopathy (LEMP) is a severe, degenerative neural disorder that occurs in young dogs and causes a progressive loss of muscle coordination. The disorder is caused by a recessive mutation to the gene NAPEPLD. The variant of LEMP analysed in this test occurs in the Leonberger. A related variant is found in the Great Dane and Rottweiler.
Onset of LEMP symptoms in affected dogs generally occurs between 1 and 2 years of age. Signs include ataxia (loss of coordination), knuckling and dragging of the paws, hypermetria (overextension of limbs while stepping) and reduced spinal reflexes. The disease progresses over a matter of months, and euthanasia will likely be required due to poor quality of life.
Pubmed ID: 29643404
Omia ID: 1788