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Leukoencephalomyeolopathy (LEMP) is a neurological disease that affects the central nervous system, affecting coordination and gait.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 18 |
| Mutation | c.345_346insC |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | LEMP |
General information
Leukoencephalomyeolopathy (LEMP) is a neurological disease that affects the central nervous system, affecting coordination and gait. The variant of the disease in this test occurs in the Great Dane and Rottweiler, and is caused by a recessive mutation to the gene LEMP. Another variant has been observed in the Leonberger.
Clinical features
Onset of LEMP occurs in juvenile dogs. Symptoms include slowly worsening gait abnormalities such as paw "knuckling", dragging of the paws, and hypermetria (overstepping while walking) of the front legs. The disease progresses over a matter of months.
Additional information
References
Pubmed ID: 29643404
Year published: 2018
Omia ID: 1788
Omia variant ID: