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Canine Spongiform Leukoencephalomyelopathy (SLEM), also known as simply Leukodystrophy, is a severe degenerative neurological disease that causes weakness, paralysis and spastic movement.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
General information
Canine Spongiform Leukoencephalomyelopathy (SLEM), also known as simply Leukodystrophy, is a severe degenerative neurological disease that causes weakness, paralysis and spastic movement. The disorder is caused by a mitochondrial mutation to the gene CYTB, and is found in the Australian Cattle Dog and the Shetland Sheepdog.
Clinical features
Affected puppies usually begin presenting with whole-body tremors at approximately 3 to 4 weeks of age. They are initially able to walk, but progressively lose coordination over several weeks of development. Other symptoms include spastic twitches of the limbs, jaw drop, difficulty swallowing, excessive salivation, failure to grow and an inability to walk. The disease is progressive, and affected dogs are typically euthanized on humane grounds.
Additional information
References
Pubmed ID: 16026996
Omia ID: 2684