57,48 47,50 excl. VAT


Leukocyte adhesion deficiency (LAD) is an autosomal recessive immunodeficiency.

10 working days






Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance


Also known as

Year Published

General information

Leukocyte adhesion deficiency (LAD) is an autosomal recessive immunodeficiency. The disease is caused by mutations in the integrin β2 subunit (ITGB2) gene, which results in the deficiency of the CD18 β-subunit. A heterodomer is formed with one of the 4 different CD11 α-subunit due to the deficieny.

Clinical features

Clinical features are omphalitis, juvenile periodontitis with loss of teeth, chronic and recurrent overwhelming bacterial infections poorly responsive to antibiotic therapy, and impaired pus formation and wound healing.

Additional information

Feline LAD exhibits features similar to LAD in other infected species. Nevertheless, feline LAD indicated a decrease of extended life expectancy under long-term antimicrobial thereapy, which can be caused due to an alternative, CD18-independent T-cell proliferation pathway.


Pubmed ID: 28750142

Omia ID: 595

How does it work?

Learn more

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

Related products