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Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption, is a disorder in which the intestines fail to absorb enough Vitamin B12.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Imerslund-Gräsbeck Syndrome (IGS), also known as Selective Intestinal Cobalamin Malabsorption, is a disorder in which the intestines fail to absorb enough Vitamin B12. This variant, found in the Beagle, is caused by a recessive mutation to the gene CUBN. Similar variants also occur in the Border Collie and Komondor.
Clinical features
Symptoms for affected dogs include lethargy, poor apetite, poor growth, weight loss and liver disease. Veterinary analysis may reveal increased protein levels in the urine.
Additional information
References
Pubmed ID: 24164695
Omia ID: 1786
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