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H712

Thyroid carcinomas (TCs) are the most common type of endocrine tumours.

10 working days

€5,95 shipping and administration per order (incl. VAT)

Only available in bundles

Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Thyroid carcinomas (TCs) are the most common type of endocrine tumours. They can originate from growth of follicular cells of the thyroid gland, which lead to familial or spontaneous thyroid follicular cell carcinomas (FCCs). The carcinomas don’t cause any signs or symptoms early in the disease. As thyroid cancer grows, it may cause swelling in the neck, voice changes and difficulties swallowing. The diagnosis is often before 10 years of age, implying an early onset of disease. FCCs occur in German longhaired pointers and are caused by autosomal recessive inherited gene mutations in the TPO gene. There are two mutations known on chromosome 17, that cause different carcinoma’s: Thyroid follicular cell carcinoma I (C>T) and Thyroid follicular cell carcinoma II (G>A).

Clinical features

Clinical signs include the presence of cervical mass, intermittent cough. In case of a hormone producing mass, alopecia, polyuria, polydipsia and lethargy can be seen.

Additional information

This test is based on a genome wide association study which described two highly associated markers. Therefore, these markers should be tested together.

References

Pubmed ID: 34464021, 34209805

Omia ID: 2380

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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