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Exercise-induced collapse (EIC) is an autosomal, recessive neuromuscular disorder.
15 working days
Border Collie, Boykin Spaniel, Chesapeake Bay Retriever, Collie, Curly-coated retriever, Labrador Retriever
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
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Exercise-induced collapse (EIC) is an autosomal, recessive neuromuscular disorder. The disorder is caused by a mutation in the dynamin 1 (DNMI1) gene, which causes an substitution in a highly conserved region of the protein. The dynamin 1 protein is functional in neurotransmission and synaptic vesicle endocytosis.
Clinical features are characterised by muscle weakness and life-threatening collapse after intense excercise. Collapse episodes generally last for 10 minutes and the dogs fully recover mostly after 30 minutes. Occasionally are the symptoms fatal.
This test is based on an association study.
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Pubmed ID: 18806795
Omia ID: 1466