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H377

Spinal Dysraphism (SD), also known as Myelodysplasia, is an inherited neurological disorder present at birth due to an error in the development of an embryo.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Spinal Dysraphism (SD), also known as Myelodysplasia, is an inherited neurological disorder present at birth due to an error in the development of an embryo. The disease is part of a group disorders known as Neural Tube Defects (NTDs).

Clinical features

Affected dogs have a defective spinal canal which are causing neurological abnormalities. Dogs may have abnormal gaits that includes simultaneous movement of the hind legs. Also known as ‘Bunny Hopping’. Other clinical signs are weakness and lack of coordination in the rear, wide-based stance, and abnormal reflexes in the hind limbs.

Additional information

References

Pubmed ID: 23874236

Omia ID: 938

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