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Cleft Lip / Palate and Syndactyly (CLPS) is a genetic abnormality that causes a closure defect in the top of the mouth (palate).
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Cleft Lip / Palate and Syndactyly (CLPS) is a genetic abnormality that causes a closure defect in the top of the mouth (palate). This condition occurs during the development of the puppy. There may also be a cleft lip and syndactyly (fused toes).
This variant of the condition occurs in the Nova Scotia Duck Tolling Retriever, and is caused by a recessive mutation to the gene ADAMTS20.
Clinical features
Clinical signs are a cleft palate, cleft lip and possible syndactyly.
Additional information
References
Pubmed ID: 25798845
Omia ID: 1140
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