€57,48 €47,50 excl. VAT
Dogs affected by X-Linked Severe Combined Immunodeficiency Disease (X-SCID) have a poorly functioning immune system.
10 working days
€5,95 shipping and administration per order (incl. VAT)
Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Dogs affected by X-Linked Severe Combined Immunodeficiency Disease (X-SCID) have a poorly functioning immune system. The disease is caused by a recessive X-linked mutation to the gene IL2RG. Because affected dogs are unable to produce a protein important for proper immune function, they are extremely susceptible to bacterial, viral and fungal infections. Even with treatment, affected pups usually die by 4 months of age.
This variant of the disorder is found in the Corgi. A related variant is found in the Basset Hound.
Clinical features
Affected dogs often show symptoms around 6 to 8 weeks of age including failure to thrive, diarrhea, intermittent vomiting and absence of palpable lymph nodes. Affected dogs may also suffer from respiratory, skin, eye or ear infections. Vaccination of affected pups with modified live virus vaccines can cause viremia and clinical signs.
Additional information
References
Pubmed ID: 8571541
Omia ID: 899
Related products
-
- Dachshund, Parson Russell Terrier, Smooth Fox Terrier, Jack Russell Terrier
- KCNJ10
- Nervous system
-
- Vizsla
- SNX14
- Nervous system
-
- All Breeds
- None
-
- Rhodesian Ridgeback
- DIRAS1
- Nervous system
