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Von-Willebrand Disease (vWD) is a group of bleeding disorders caused by deficiency in the von Willebrand factor (vWF), which results in poorly functioning blood platelets and can lead to uncontrolled bleeding.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Von-Willebrand Disease (vWD) is a group of bleeding disorders caused by deficiency in the von Willebrand factor (vWF), which results in poorly functioning blood platelets and can lead to uncontrolled bleeding. Type III (Type 3) vWD is the most severe form of the disease, and is caused by a recessive mutation to the gene vWF. This variant of Type III vWD is found in the Scottish Terrier. Related variants are also found in the Shetland Sheepdog and Dutch Kooiker.
Clinical features
Von Willebrand Disease causes disorders of blood clotting which can lead to symptoms such as easy bruising or bleeding. These dogs are often at risk for excessive bleeding during veterinary procedures.
Additional information
References
Pubmed ID: 10668811
Omia ID: 1058