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Trapped Neutrophil Syndrome (TNS) is a hereditary immune disease common to Border Collies.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Trapped Neutrophil Syndrome (TNS) is a hereditary immune disease common to Border Collies. Affected dogs’ bone marrow is unable to properly release white blood cells into the bloodstream, causing various bodily complications as well as an extreme vulnerability to infections due to a poor immune system. TNS is therefore often fatal within the first year. It is caused by a recessive mutation to the gene VPS13B.
Clinical features
Affected puppies suffer from infections due to a compromised immune system. They are smaller and weaker than their littermates, and may develop an abnormally lengthened head and/or legs. Onset can be anywhere between six months and two years of age.
Additional information
References
Pubmed ID: 21605373
Omia ID: 1428