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Acral Mutiliation Syndrome (AMS) is a severe neurological disorder found in several Pointer and Spaniel breeds.
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Specifications
| Breeds | English Cocker Spaniel, English Pointer, English Springer Spaniel, French Spaniel, German Shorthaired Pointer |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Acral Mutiliation Syndrome (AMS) is a severe neurological disorder found in several Pointer and Spaniel breeds. AMS causes a loss of pain sensitivity in the limbs, often leading to affected dogs aggressively licking or biting at their own paws, severely injuring them without noticing. The disorder is caused by a recessive mutation to the gene GDNF.
Clinical features
Onset of AMS symptoms occurs at approximately 4 months of age. Affected puppies lose sensation in their paws and often lick or bite at them. This results in ulcers, claw loss, painless bone fractures and ultimately amputated toes. There is no loss of motor control or coordination.
Additional information
References
Pubmed ID: 28033318
Omia ID: 1514
Year published: