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Spongiform Leukoencephalomyelopathy (SLEM) also known as shaking puppy syndrome (SPS), is an autosomal recessive disease for the Border Terrier breed.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Also known as

General information

Spongiform Leukoencephalomyelopathy (SLEM) also known as shaking puppy syndrome (SPS), is an autosomal recessive disease for the Border Terrier breed. Puppies with this disease show uncontrollable shaking of their hind limbs as soon as they first attempt to stand and walk. As the puppies grow, the shaking may spread to the entire body and the prognosis is generally poor.

Clinical features

Clinical signs include severe tremors, primarily in the hindquarters, which manifest as uncoordinated wagging of the tail and body. These tremors typically stop when the puppy is asleep.

Affected puppies struggle with feeding and may exhibit delayed growth. Unfortunately, many affected pups are euthanized due to welfare concerns. However, a small number have shown signs of recovery with attentive nursing care and have developed into relatively normal adults.

Additional information

References

Pubmed ID:

Omia ID:

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.