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Reduced fertility can have various causes, including both genetic and environmental factors.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 23 |
| Organ | |
| Specimen | Hair, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | FH10 |
General information
Reduced fertility can have various causes, including both genetic and environmental factors. Recently, two genetic variants associated with early embryonic recessive lethality have been identified in the Friesian horse breed: FH4 and FH10. The variant tested in this assay is known as FH10 and is likely caused by an autosomal recessive mutation on chromosome 23. The mutation is a big deletion (261Kb) encompassing several non-coding RNAs that are, amongst others, involved in spermatogenesis. Studies estimate that approximately 16% of Friesian horses are carriers of this variant.
Clinical features
There are indications that sires carrying this variant have a reduced fertility. Furthermore, mating two carrier animals results in a 25% chance of producing homozygous embryos, which are most likely non-viable and die during early embryonic development. As a result, the mare will return to estrus (heat). The reduced fertility associated with FH10 is therefore associated with both a reduced fertility in sires and by the genetic combination of both parents.
Additional information
References
Pubmed ID: Unpublished
Year published: 2025
Omia ID: Unknown
Omia variant ID: