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Polymyositis is a muscle disease in which inflammation of the muscles leads to difficulties with movement and swallowing.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as |
General information
Polymyositis is a muscle disease in which inflammation of the muscles leads to difficulties with movement and swallowing. This variant occurs in the Dutch Kooikerhondje and is a complex genetic disorder involving multiple gene mutations. Dogs that are homozygous for this mutation have a minimum of 10% chance for developing the condition, while heterozygous animals have approximately a 1% chance.
Clinical features
The disease can start at a young age, but the symptoms and severity vary greatly between dogs. The most noticeable symptoms include an abnormal gait, general muscle weakness, and muscle stiffness. Swallowing difficulties may also occur. Additionally symtoms, such as lethargy, weight loss, reduced endurance, and respiratory issues can be present.
Additional information
This DNA test is conducted in cooperation with the Expertise Centre Genetics of Companion Animals of Utrecht University.
Explanation of results:
WW = Your Kooikerhondje is clear of the risk factor for polymyositis. The dog is clear of the DNA variant that is involved in the development of polymyositis in the Kooikerhondje. This means that the risk of the disease is extremely low.
WM = Your Kooikerhondje is a heterozygote for the risk factor for polymyositis. The dog is a heterozygous carrier and has one copy of the DNA variant that is involved in the development of polymyositis in the Kooikerhondje. This means that the risk of the disease is limited at approximately 1%.
MM = Your Kooikerhondje is homozygous for the risk factor for polymyositis. The dog is homozygous for the risk factor and has two copies of the DNA variant that is involved in the development of the disease. Therefore, the dog has an increased risk to get polymyositis. The risk is estimated to be at least 10%. We advise to have the CK (= CPK) level of the blood of your dog measured at routine visits to your veterinarian. An increased level is indicative of polymyositis. Clinical signs that may be noticed are difficulty swallowing and difficulty walking with a stiff stride.
References
Pubmed ID: University of Utrecht
Omia ID: