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Long QT Syndrome in dogs is a genetic heart condition that affects the electrical activity of the heart.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Long QT Syndrome in dogs is a genetic heart condition that affects the electrical activity of the heart. In the English Springer Spaniel it is caused by an autosomal dominant genetic mutation in the KCNQ1 gene. This gene is involved in the activity of the heart’s ion channels and the mutation leads to an abnormal heart rhythm in which the ventricles may end up out of sync with the rest of the heart (a.k.a. ventricular tachycardia).
Clinical features
Dogs with this condition can have episodes of fainting/collapse, seizures, weakness, lethargy and, in some cases, sudden death. The first signs of this disease are often in adulthood.
Additional information
References
Pubmed ID: 25779927
Omia ID: 2332