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Haemophilia A, also known as Factor VIII Deficiency, is the most prevalent bleeding disorder in dogs.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Haemophilia A, also known as Factor VIII Deficiency, is the most prevalent bleeding disorder in dogs. This X-linked recessive condition is triggered by a mutation in the gene F8, which severely compromises the blood’s clotting ability. Dogs affected by Haemophilia A may exhibit symptoms like spontaneous internal bleeding or uncontrolled bleeding following injuries or surgical procedures. These manifestations are a result of the impaired clotting mechanism in the bloodstream. As an X-linked recessive disorder, it predominantly affects male dogs, while female dogs usually act as carriers.
This specific variant of the disease (HEMA-2)occurs in the German Shepherd. Different variants of the mutation are found in other breeds including the Irish Setter, Miniature Schnauzer, Boxer, Old English Sheepdog and the Rhodesian Ridgeback.
Clinical features
The main symptom of haemophilia is easy or spontaneous bleeding and/or bruising. Affected dogs may develop hematomas (soft, blood-filled swellings under the skin, bruises), bleed from the gums, or might develop internal bleeding in the joints (causing lameness) or in the chest or abdomen (which can be life-threatening). Bleeding after trauma or a medical procedure is also likely to be severe.
Additional information
References
Pubmed ID: 25040606
Omia ID: 437