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Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris. It is often due to genetics and is commonly seen in certain breeds. One of the genes involved in this trait is the Paired Box 3 (PAX3) gene. Mutations in the gene can result in white spotting, deafness, pigmentary disturbances in one or two eyes and in some cases also embryonic or fetal lethality.
There are multiple mutations known. The variant tested here is found in Maine Coon cats.
Clinical features
Cats with this mutation show one or two blue eyes or particolored eyes and minimal white spotting. This does not necessarily indicate any underlying health issues. In different feline breeding lines deafness has been identified as being associated with this trait.
Additional information
The mating of two heterozygous cats is not recommended in order to prevent the production of homozygous kittens, which is embryonic or fetal lethal.
Additionally, mating a carrier with a wild-type animal is also not recommended to prevent the birth of blue-eyed deaf cats.
References
Pubmed ID: 38869246
Omia ID: 1688