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Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Dominant Blue Eyes (DBE) in cats are typically associated with a lack of melanin in the iris. It is often due to genetics and is commonly seen in certain breeds. One of the genes involved in this trait is the Paired Box 3 (PAX3) gene. Mutations in the gene can result in white spotting, deafness, pigmentary disturbances in one or two eyes and in some cases also embryonic or fetal lethality. The tested mutation for the Celestial line is characterised by an autosomal dominant inheritance with variable expressivity and incomplete penetrance for both white spotting and blue eyes, and pleiotropy.
There are multiple mutations known. The variant tested here is found in the Celestial Maine Coon line, Siberian and Celestial cats.
Clinical features
Cats with this mutation might show one or two blue eyes or particolored eyes and minimal white spotting. This does not necessarily indicate any underlying health issues. In different feline breeding lines deafness has been identified as being associated with this trait.
Additional information
After consulting with a researcher involved in the study of mutations for blue eyes in cats. This revealed that this test is specific to the Celestial Maine Coon line. In the publication on this research, only this specific line is mentioned, and there is no scientific evidence for the presence of this mutation in the regular Maine Coon population.
References
Pubmed ID: 38644700
Omia ID: 1688