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Craniomandibular Osteopathy (CMO), sometimes referred to as “lion’s jaw,” is a developmental bone disorder that affects the skull and jaw bones of young, growing dogs.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
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General information
Craniomandibular Osteopathy (CMO), sometimes referred to as “lion’s jaw,” is a developmental bone disorder that affects the skull and jaw bones of young, growing dogs. It is caused by a mutation in the SLC35D1 gene. It has been observed in individual cases within the Weimaraner breed, but the inheritance pattern remains unconfirmed
Clinical features
The CMO causes abnormal bone growth, most commonly in the mandible and tympanic bullae, and typically manifests between 3 and 8 months of age. Affected puppies may show firm swelling around the jaw, pain when opening the mouth, drooling, difficulty eating, reduced appetite, fever, lethargy, and weight loss. In some cases, additional cranial bones and joints may be involved, leading to further discomfort or impaired function. In most dogs, abnormal bone growth from CMO stops when growth ends (10–13 months), with pain and inflammation resolving and symptoms often disappearing as the bone partly remodels. Some may retain mild thickening without problems, while severe early changes can cause permanent jaw deformity or restricted movement, though this is rare with timely care.
Additional information
References
Pubmed ID: 32033218
Omia ID: Not Available