Copper Toxicosis (RETN)

Copper Toxicosis is a complex genetic disease in the Labrador Retriever, Golden Retriever and other breeds. Affected dogs retain too much copper from their diet, causing liver damage and associated negative effects. Several different mutations can contribute to this disorder, including a mutation to the ATP7B gene (referred to as Wilson Disease). Literature indicates that the dominant mutation to RETN analyzed in this test reduces hepatic copper levels, potentially protecting against copper toxicosis. The condition Menkes Disease has been documented to have a similar effect. Copper toxicosis can also be mitigated with a low-copper, high-zinc specialized diet.