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Bunny Hopping Syndrome (BHS1) is an autosomal recessive movement disorder that affects the Weimaraner breed.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Bunny Hopping Syndrome (BHS1) is an autosomal recessive movement disorder that affects the Weimaraner breed. In dogs with BHS1, nerve pathways in the spinal cord switch sides. This alteration prevents affected dogs from controlling each hind leg independently, leading to the characteristic bunny hopping gait. This gait might be occasionally observed in the front legs as well, though the primary focus is on the hind legs. The disorder is caused by a mutation in the EFNB3 gene that results in spinal cord malformations during embryonic development.
Clinical features
This condition is characterized by a unique movement pattern, where the hind legs move simultaneously in a hopping motion, resembling that of a bunny. Other symptoms include rear leg weakness and lack of coordination, while the front legs remain coordinated and strong.
The condition of BHS1-affected puppies does not improve over time. Consequently, euthanasia is often considered on human grounds for affected individuals.
Additional information
References
Pubmed ID: Unpublished data University of Bern
Omia ID: