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Australian Labradoodle Dystrophinopathy is a variant of the sex-linked muscle disorder Duchenne Muscular Dystrophy (DMD) specific to the Australian Labradoodle.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Australian Labradoodle Dystrophinopathy is a variant of the sex-linked muscle disorder Duchenne Muscular Dystrophy (DMD) specific to the Australian Labradoodle. Like other forms of DMD, Australian Labradoodle Dystrophinopathy causes damage to the skeletal and cardiac muscles and ultimately death. It is caused by a recessive mutation to the DMD gene.

Clinical features

Affected puppies develop symptoms of muscle decline as early as 3 months of age. Signs include decreased walking, a plantigrade (flat-footed) stance and a stiff or shuffling gait, difficulty swallowing, a swollen tongue, excessive salivation, weakness, weight loss and muscle atrophy. The disease progresses quickly, and death by heart failure can occur within several months of initial symptoms.

Additional information

References

Pubmed ID: 30286978

Omia ID: 1081

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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