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American Staffordshire Terrier Juvenile Laryngeal Paralysis and Polyneuropathy (ALPP) is a severe neurological disorder characterized by difficulty breathing and loss of muscle coordination.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Also known as |
General information
American Staffordshire Terrier Juvenile Laryngeal Paralysis and Polyneuropathy (ALPP) is a severe neurological disorder characterized by difficulty breathing and loss of muscle coordination. This variant, observed in the American Staffordshire Terrier, is caused by an autosomal recessive genetic mutation.
Clinical features
Affected dogs typically present around 3 months of age with laryngeal paralysis and respiratory distress. Loss of movement coordination often develops a few months to a few years later. Additional symptoms may include limb weakness, ataxia (loss of coordination), progressive muscle atrophy, altered barking (dysphonia), vomiting, and swallowing difficulties. In some cases, symptoms may stabilize, although episodes of ataxia and swallowing difficulties may persist. The dogs of which symptoms stabilize, seem to lead an almost normal life.
Additional information
This test is performed by an external laboratory. CombiBreed takes care of the mediation between you as a customer and the external laboratory. In this case, CombiBreed cannot be held liable for the behaviour of the client and/or contractor.
References
Pubmed ID: Unpublished data University of Missouri
Omia ID: 1970