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Primary Lens Luxation (PLL) is an eye condition in which the lens detaches from its normal attachments, leading to displacement (luxation), inflammation, glaucoma, and potential blindness.
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Specifications
| Breeds | Chinese Crested, Patterdale Terrier, Sealyham Terrier, Volpino Italiano, German Hunting Terrier, Jack Russell Terrier, Lancashire Heeler, Miniature Bull Terrier, Parson Russell Terrier, Rat Terrier, Tenterfield Terrier, Tibetan Terrier, Toy Fox Terrier, Welsh Terrier, Yorkshire Terrier |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Primary Lens Luxation (PLL) is an eye condition in which the lens detaches from its normal attachments, leading to displacement (luxation), inflammation, glaucoma, and potential blindness. PLL is caused by an autosomal recessive mutation in the ADAM metallopeptidase with thrombospondin type 1 motif 17 (ADAMTS17) gene.
Clinical features
Symptoms of PLL include: redness of the eye, squinting, tearing, a bluish or cloudy haze over the cornea, and visible lens displacement. Early symptoms of PLL can be observed from 20 months of age on. Complete luxation usually appears between 3-8 years of age.
Additional information
References
Pubmed ID: 20375329
Omia ID: 588