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Primary Hyperoxaluria (PH) is a severe metabolic disorder found in the Coton de Tulear.
10 working days
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
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Primary Hyperoxaluria (PH) is a severe metabolic disorder found in the Coton de Tulear. The disease, which causes the buildup of oxalate crystals in the kidneys and typically leads to death within weeks, is caused by a recessive mutation to the gene AGXT.
Affected puppies present with signs of kidney failure at 3 to 4 weeks of age. These symptoms can include lack of apetite, lethargy, vomiting, decreased urine production and bloody urine. The disease is severe, and euthanasia is typically necessary within a week.
Pubmed ID: 22486513
Omia ID: 1672