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Primary hyperoxaluria (PH) in cats is a genetic disorder caused by a recessive mutation in the GRHPR gene.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Primary hyperoxaluria (PH) in cats is a genetic disorder caused by a recessive mutation in the GRHPR gene. The disorder is characterized by the overproduction of oxalate, which can lead to various urinary and kidney issues.
Clinical features
Oxalate accumulation can lead to urinary crystals or stones that can be painful and potential cause urinary system blockages and kidney damage and impaired function over time. Furthermore, affected kittens might show the following symptoms, depending on the location of the urinary stones: increased urination frequency, straining to urinate, blood in urine (hematuria), increased water intake and other symptoms of kidney failure and urinary tract blockage. When symptoms are severe, euthanasia on humane grounds can be performed. Symptoms appear usually between five and nine months of age.
Additional information
References
Pubmed ID:
Omia ID: 821