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Canine Progressive Retinal Atrophy (PRA) refers to a group of inherited blinding canine diseases.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Canine Progressive Retinal Atrophy (PRA) refers to a group of inherited blinding canine diseases. The form of adult-onset PRA in the Basenji is characterised by photoreceptor degeneration causing progressive vision loss, culminating in blindness. It is caused by a recessive mutation to the gene SAG.

Clinical features

Initial symptoms are visual loss in dim light (night blindness), which gradually progresses to total blindness. Unless the dog is used for high visual performance tasks such as agility work, the reduction in the visual field (tunnel vision) may not be noticed. Despite tunnel vision and night blindness, many affected Basenjis retain adequate forward daylight vision for many years, sometimes for their entire natural life.

Additional information

References

Pubmed ID: 24019744

Omia ID: 1876

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3. Results

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