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H373

Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision.

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Specifications

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision. This variant of PRA, Progressive Retinal Atrophy type 3, occurs in the Tibetan Spaniel and Tibetan Terrier. It is associated with by a recessive mutation to the gene FAM161A.

Clinical features

Affected dogs generally show the first signs of night blindness between three and seven years of age. After the initial signs present, the disease can progress rapidly, often leading to complete loss of vision within one year. Opthalmological examination can reveal thinning of the retinas.

Additional information

The mutation in this test is a risk factor, and has not yet been established as the sole cause of the disorder.

References

Pubmed ID: 24705771

Omia ID: 1918

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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