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Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs.
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Specifications
| Breeds | Biewer Terrier, Huntaway, New Zealand Heading Dog, Norwegian Lundehund, Poodle (Standard), Belgian Malinois, Schnauzer stándard, Beagle, Cocker Spaniel, Rottweiler, Shetland Sheepdog, Shih-Tzu, Yorkshire Terrier |
|---|---|
| Gene | |
| Chromosome | 16 |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant |
General information
Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs. Specifically, polydactyly restores the first toe that was lost over the course of the evolution of the wolf, giving affected dogs a fifth toe known as a “dewclaw”. This specific variant (DC-2) is caused by a dominant mutation to the Limb Development Membrane Protein 1 (LMBR1) gene that affects the expression of the sonic hedgehog (SHH) gene.
This test measures the mutation known as DC-2. Another mutation, DC-1, is found in Sapsari and Tosa dogs.
Clinical features
Affected dogs develop an extra toe, or dewclaw, on their hind legs.
Additional information
References
Pubmed ID: 18689889
Year published: 2008
Omia ID: 810
Omia variant ID: