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H984

Paradoxical Pseudomyotonia is a hereditary muscular disease that causes general muscle stiffness after exercise.

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Specifications

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Year Published

General information

Paradoxical Pseudomyotonia is a hereditary muscular disease that causes general muscle stiffness after exercise. The disorder is found in the English Cocker Spaniel and English Springer Spaniel, and is caused by a recessive mutation to the gene SLC7A10.

Clinical features

Affected dogs present within the first two years of age (generally at approximately 6 months) with episodes of exercise-caused myotonia. These episodes result in generalized muscle stiffness and may cause affected dogs to walk strangely (described sometimes as “running in a computer game”), or get stuck while climbing stairs or jumping. In more severe cases, the dog may collapse and have difficulty breathing. Episodes typically last for several seconds to under one minute, and resolve with rest. They are caused by strenuous exercise, and may be worsened by stress, excitement, and particularly high or low temperatures.

Additional information

References

Pubmed ID: 36869603

Omia ID: 2645

How does it work?

1. Select your product(s)

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2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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