57,48 47,50 excl. VAT

H337

Neuronal Ceroid Lipofuscinosis (NCL) is a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death.

10 working days

€5,95 shipping and administration per order (incl. VAT)

Specifications

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Neuronal Ceroid Lipofuscinosis (NCL) is a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This variant, Neuronal Ceroid Lipofuscinosis type 8 (NCL8), occurs in the Australian Shepherd and German Shorthaired Pointer. It is caused by a recessive mutation to the gene CLN8. Other breeds that carry mutations for NCL8 include the English Setter, Alpenländische Dachsbracke, and Saluki

Clinical features

Affected dogs begin to present symptoms between 10 and 20 months of age, primarily impaired vision and ataxia (loss of coordination). This can result in compulsive circling movements, jaw chattering, loss of housetraining, decreased responsiveness to voice commands and agitation at noises. The disease is progressive, and euthanasia may ultimately be necessary due to poor quality of life.

Additional information

References

Pubmed ID: 24953404

Omia ID: 1506

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

Related products