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Canine neuroaxonal dystrophy (NAD) is a degenerative, recessive neurological disease of young adult Rottweiler dogs.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Canine neuroaxonal dystrophy (NAD) is a degenerative, recessive neurological disease of young adult Rottweiler dogs. The disease is characterised by targeting sensory axon terminals by axonal spheroids, whereby axonal swellings occur in the central or peripheral nervous system. The neurological disorder is caused by a missense mutation within the Vacuolar Protein Sorting 11 (VPS11).
Clinical features
Clinical features includes nystagmus, intention tremor, hypermetria, ataxia, postural deficits.
Additional information
This test is based on a genome-wide association study.
References
Pubmed ID: 29945969
Omia ID: 2152
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